Hope floats? $10 million grant to study marine neurobiology

Two female researchers in a laboratory setting, both wearing white lab coats and safety glasses, are engaged in a scientific experiment. The researcher on the left, with her hair in a braid and wearing gold hoop earrings, looks intently at the equipment. The researcher on the right, with light brown hair pulled back and wearing pink gloves, is smiling as she adjusts an instrument. The background is filled with shelves containing various lab supplies, equipment, and scientific instruments, indicating a busy and well-equipped research environment, likely at the Scripps Institution of Oceanography.

A new center, led by UC San Diego researchers, will focus on the impacts of climate change on marine species’ nervous systems.

UC San Diego’s Scripps Institution of Oceanography has received a four-year, $10 million grant, funded by the Paul G. Allen Family Foundation and the Paul G. Allen Frontiers Group, to establish the Allen Discovery Center for Neurobiology in Changing Environments.

The center will take a multidisciplinary approach to investigating how climate change may impact the nervous systems and behavior of marine animals, and its lead scientist hopes this study will carry hope forward for adaptation to such change.

Marine biologist and physiologist Martin Tresguerres, who has spent his career studying how marine animals function, is particularly interested in “how climate change might impact those functions, and if there is a scope for certain species to do better than others,” he said.

The grant is “unusual,” Tresguerres said, in that it establishes a collaboration of 13 scientists from several distinct disciplines, instead of funding one lab.

The center unites researchers from Scripps Oceanography and across the UCSD campus, the University of Southern California, Carnegie Science, the University of Virginia and MacEwan University in a diverse team of experts in marine biology, neurobiology and genomics.

“Having this center will allow us to look at this problem … from biological complexity, from genes to cells to organisms, and also to look at the relevance for the natural environment,” Tresguerres said.

What is “the problem?” 

The problem is climate change: “We’re going to focus on the effects of warming, elevated temperatures, hypoxia (lower oxygen levels in the water) and acidification, which is caused by increased carbon dioxide,” he said.

Many of the essential functions carried out by marine animals, from selecting a place to settle and sourcing food to finding a mate and reproducing, are coordinated by the organism’s nervous system, Tresguerres explained. 

All of these functions “work optimally or better under certain conditions,” he said. If water temperature or other conditions are modified, some functions may still happen but worsen while others cease to happen.

But some animals “might have the ability to switch, or modify, their system to … work better at the new temperature, or they can work better with lower oxygen levels,” Tresguerres said.

What researchers at the new center will ask, he said, is “whether this ability that animals have to adapt to naturally changing environments will still be good enough to deal with changes due to human-induced climate change, which could be a lot more rapid and more pronounced.”

The team will work to identify the mechanisms that make animals capable of adapting to climate change, including any genetic and cellular mechanisms.

This identification might allow scientists to “predict which species are more vulnerable, which ones are more resilient,” Tresguerres said. “That can help efforts for conservation.”

“Let’s say you want to introduce a certain population of fish to try to counteract the effects of climate change,” he said. “Our research hopefully will help identify the strains or species that are more persistent.”

Tresguerres relates that hypothetical optimism to modalities of human health, in which some humans are more resistant to certain viruses, a feature used to help design vaccines and treatments.

Knowing why some marine animals are more affected by climate change than others, he said, “can lead to science-based solutions.”

Study details

The researchers at the center will focus on four marine species, all of which Tresguerres said are “very important ecologically”: staghorn coral, the slipper snail, the painted sea urchin and the three-spined stickleback fish.

Nine of the 13 scientists are based at UCSD and/or SIO, where the painted sea urchin is often found.

The painted sea urchin is “very, very important,” Tresguerres said, “because they live in kelp forests, and they can help eat different algae [and] keep everything at bay.”

By noting how the sea urchin behaves during climate change, the team will be able to see how the kelp forests will fare.

Species related to the slipper snail can also be found locally, along with the stickleback fish, which is found here north to Alaska, Tresguerres said.

The grant has the potential to be extended another four years, he said, which he hopes will happen to deepen scientists’ understanding.

He applauded the Allen Frontiers Group funding, noting “this level of funding [will] make a big difference, because we can explore all of these things in an integrated manner.”

Photography by Erik Jepsen.

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Elisabeth Frausto

Elisabeth Frausto has been reporting on and writing about La Jolla since 2019. With dozens of local and state journalism awards to her name, Elisabeth knows the industry as well as she knows her community. When she’s not covering all things 92037, you’ll find her with coffee in hand staring at the sea.

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